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by altering the pattern of activation of the nicotine receptors (that is, their sensitivity to neurotransmitter)

[26] According to Philip Morris International, 384.8 million Zyn cans were sold worldwide in 2023, up 62% from 237 million cans in 2022

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These strategies align with the Theoretical Domains Framework, which emphasises reducing environmental resources that enable risky behaviours (85)

Among them were Backpack Boyz carts with as many as two dozen pesticides, half of those above state safety limits and including chlorfenapyr, prohibited at any amount, at 2,000 times above the minimum detection level